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• Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

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• Chun-Hao Pan, Nina V. Chaika, Robert Tseng, Md Afjalus Siraj, Bo Chen, Katie L. Donnelly, Michael Horowitz, Cindy V. Leiton, Sumedha Chowdhury, Lucia Roa-Peña, Lyanne Oblein, Natalia Marchenko, Pankaj K. Singh, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos

       bioRxiv 2022.08.24.504873; doi: https://doi.org/10.1101/2022.08.24.504873

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• Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

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• Ryan R. Kawalerski, Mariana Torrente Gonçalves, Chun-Hao Pan, Robert Tseng, Lucia Roa-Peña, Cindy V.        Leiton, Luke A. Torre-Healy, Taryn Boyle, Sumedha Chowdhury, Natasha T. Snider, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos

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• bioRxiv 2022.08.27.504988; doi: https://doi.org/10.1101/2022.08.27.504988

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• Baraks G, Tseng R, Pan CH, Kasliwal S, Leiton CV, Shroyer KR, Escobar-Hoyos LF. Dissecting the Oncogenic Roles of Keratin 17 in the Hallmarks of Cancer. Cancer Res. 2022 Apr 1;82(7):1159-1166. doi: 10.1158/0008-5472.CAN-21-2522. PMID: 34921015; PMCID: PMC9016724.

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• Sruthi Babu, MD, PhD, Nam W Kim, PhD, Maoxin Wu, MD, PhD, Ina Chan, Luisa F Escobar-Hoyos, PhD, Kenneth R Shroyer, MD, PhD, Keratin 17 Is a Novel Cytologic Biomarker for Urothelial Carcinoma Diagnosis,  American Journal of Clinical Pathology, Volume 156, Issue 5, November 2021, Pages 926–933, https://doi.org/10.1093/ajcp/aqab050

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• Roa-Peña L, Babu S, Leiton CV, Wu M, Taboada S, Akalin A, Buscaglia J, Escobar-Hoyos LF, Shroyer KR. Keratin 17 testing in pancreatic cancer needle aspiration biopsies predicts survival. Cancer Cytopathol. 2021 Nov;129(11):865-873. doi: 10.1002/cncy.22438. Epub 2021 Jun 2. PMID: 34076963; PMCID: PMC9014629.​

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• Neutralizing activity to SARS-CoV-2 of convalescent and control plasma used in a randomized controlled trial. Freedenberg AT, Pan CH, Diehl WE, Romeiser JL, Hwang GR, Leiton CV, Muecksch F, Shroyer KR, Bennett-Guerrero E. Transfusion. 2021 Jan 15:10.1111/trf.16283. doi: 10.1111/trf.16283. Online ahead of print. PMID: 33448402 
   

• Fassler DJ, Abousamra S, Gupta R, et al. Deep learning-based image analysis methods for brightfield-acquired multiplex immunohistochemistry images. Diagn Pathol. 2020;15(1):100. Published 2020 Jul 28. doi:10.1186/s13000-020-01003-0

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• Haye K, Babu S, Oblein L, et al. Keratin 17 Expression Predicts Poor Clinical Outcome in Patients With Advanced Esophageal Squamous Cell Carcinoma [published online ahead of print, 2020 Jun 16]. Appl Immunohistochem Mol Morphol. 2020;10.1097/PAI.0000000000000862. doi:10.1097/PAI.0000000000000862

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• Pan CH, Otsuka Y, Sridharan B, et al. An unbiased high-throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer. Mol Oncol. 2020;14(8):1800-1816. doi:10.1002/1878-0261.12743

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• Bai JDK, Babu S, Roa-Peña L, et al. Keratin 17 is a negative prognostic biomarker in high-grade endometrial carcinomas. Hum Pathol. 2019;94:40-50. doi:10.1016/j.humpath.2019.09.005

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• Roa-Peña L, Leiton CV, Babu S, et al. Keratin 17 identifies the most lethal molecular subtype of pancreatic cancer. Sci Rep. 2019;9(1):11239. Published 2019 Aug 2. doi:10.1038/s41598-019-47519-4

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• Alvi E, Gupta R, Borok RZ, Escobar-Hoyos L, Shroyer KR. Overview of established and emerging immunohistochemical biomarkers and their role in correlative studies in MRI. J Magn Reson Imaging. 2020;51(2):341-354. doi:10.1002/jmri.26763

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• Gao M, Lin M, Rao M, et al. Development of Patient-Derived Gastric Cancer Organoids from Endoscopic Biopsies and Surgical Tissues. Ann Surg Oncol. 2018;25(9):2767-2775. doi:10.1245/s10434-018-6662-8​

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• Keratin 17 is a sensitive and specific biomarker of urothelial neoplasia. Mod Pathol. 2018. doi: 10.1038/s41379-018-0177-5

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• Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images. Cell Rep. 2018 Apr 3;23(1):181-193.e7. doi: 10.1016/j.celrep.2018.03.086. PMID: 29617659

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• Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival. Head Neck. 2018;40(8):1788-1798. doi: 10.1002/hed.25164. PMID: 29626364

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• Keratin 17 Is a Prognostic Biomarker in Endocervical Glandular Neoplasia. Am J Clin Pathol. 2017;148(3):264-273. doi: 10.1093/ajcp/aqx077. PMID: 28821199

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• B7-H4 is Inversely Correlated With T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer. Appl Immunohistochem Mol Morphol. 2017 Oct 20. doi: 10.1097/PAI.0000000000000608. PMID: 29189263

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• Keratin 17 is overexpressed and predicts poor survival in estrogen receptor-negative/human epidermal growth factor receptor-2-negative breast cancer. Hum Pathol. 2017;62:23-32. doi: 10.1016/j.humpath.2016.10.006. PMID: 27816721

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• Unmet clinical needs in cervical cancer screening. MLO Med Lab Obs. 2016;48(1):8, 10, 14; quiz 15. PMID: 26887092

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• Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility. Cancer Res. 2015;75(17):3650-62. doi: 10.1158/0008-5472.CAN-15-0293 PMID: 26109559

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• Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker. Mod Pathol. 2013;27(4):621-30. doi: 10.1038/modpathol.2013.166 PMID: 24051697

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